Cancer BiologybioRxiv
Mutant-selective Degradation by BRAF-targeting PROTACs
S. Alabi, S. Jaime-Figueroa, Z. Yao…·C. M. Crews
This study develops BRAF-targeting PROTACs that degrade all BRAF mutants at sub-nanomolar concentrations while sparing wild-type RAF family members, showing in vivo efficacy and mechanistic insights.
DOI 10.1038/s41467-021-21159-7