Z. Yao

SARS-CoV-2 vaccination during pregnancy enhances hippocampal neurogenesis and working memory in offspring via IFN-gamma responsive microglia

This study shows maternal SARS-CoV-2 vaccination increases hippocampal neurogenesis and working memory in offspring mice via IFN-gamma responsive microglia.

Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice

This study shows that systemic bumetanide administration after cardiac arrest and CPR improves survival, reduces brain injury, and prevents multiple organ dysfunction in male mice, with LCN2/NGAL identified as a potential biomarker for early neuroprognostication.

Multi-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells

The paper introduces a multi-scale proximity labeling method using Eosin Y to map cell surface protein neighborhoods at varying resolutions and validates interactions of EGFR and CAR-T cell synapses.

AAV-HBV mouse model replicates immune exhaustion patterns of chronic HBV patients at single-cell level

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

The paper identifies conserved antiviral pathways across macaques and humans using transcriptomic data from viral infections, showing shared and virus-specific responses that inform pandemic preparedness.

Chikungunya virus glycoproteins transform macrophages into productive viral dissemination vessels.

This study identifies CHIKV glycoproteins E2 and E1 as key factors that enable macrophages to support viral replication and dissemination by counteracting host restriction factors.

Redundant and distinct roles of two 14-3-3 proteins in Fusarium sacchari, pathogen of sugarcane Pokkah boeng disease

This study investigates the roles of two 14-3-3 proteins in Fusarium sacchari, showing redundancy and distinct functions in pathogenicity and development.

Omicron Spike Protein Is Vulnerable to Reduction

This study shows that Omicron SARS-CoV-2 spike proteins are more susceptible to reduction due to mutations in the receptor binding module, which affects their stability and binding activity.

Global and cell type-specific immunological hallmarks of severe dengue progression

This study identifies DENV target cells and immunological changes in severe dengue progression using single-cell RNA-Seq and functional assays in children.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

MMD scaffolds ACSL4 and MBOAT7 to promote polyunsaturated phospholipid synthesis and susceptibility to ferroptosis

This paper identifies MMD as a scaffold protein that promotes ferroptosis by facilitating the synthesis of arachidonoyl-phospholipids through interactions with ACSL4 and MBOAT7.

Ubiquitin-based pathway acts inside chloroplasts to regulate photosynthesis

The paper shows the ubiquitin-proteasome system targets proteins inside chloroplasts, including chloroplast-encoded photosynthesis subunits, via the CHLORAD pathway.

Met-HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells

The paper identifies a HER3-MPZL3 axis that supports proliferation in MET-amplified cancer cells through tyrosine phosphorylation and interaction.

Lin28a rejuvenates muscle stem cells via mitochondrial optimization

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetes

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

Multiplexed bioluminescence microscopy via phasor analysis

This paper introduces a method combining bioluminescence with phasor analysis to rapidly differentiate multiple luciferase reporters and resonance energy transfer processes in time-lapse imaging.

The RNA-binding protein HuR promotes nonalcoholic steatohepatitis (NASH) progression by enhancing death signaling pathway

This study shows HuR promotes NASH by enhancing DR5/caspase8/caspase3-mediated hepatocyte death through stabilizing DR5 mRNA.

The impact of preprint servers in the formation of novel ideas

The paper estimates the time of appearance of phrases in biomedical literature to assess whether novel ideas first appear in preprints or traditional journals, finding most appear in journals but some in preprints.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

Mutant-selective Degradation by BRAF-targeting PROTACs

This study develops BRAF-targeting PROTACs that degrade all BRAF mutants at sub-nanomolar concentrations while sparing wild-type RAF family members, showing in vivo efficacy and mechanistic insights.

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection

This study uses single-cell RNA sequencing to analyze the host and viral RNA dynamics during VEEV infection, identifying superproducer cells and candidate antiviral targets.

Rapid multicomponent bioluminescence imaging via substrate unmixing

This paper introduces a method for rapid, multiplexed bioluminescence imaging using substrate unmixing to detect multiple luciferases in vitro and in vivo.

Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity.

This study identifies TIM-1 and endocytic pathways as key mediators of exosome entry and cargo delivery for IFN-α-induced antiviral activity transfer from macrophages to hepatocytes.