Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)
R. Dong, K. A. Libby, F. Blaeschke, A. Marson, R. D. Vale, X. Su
This study shows CAR T cells bypass LAT for some signaling outputs but still require it for IL-2 production, revealing a rewired signaling pathway.
bioRxiv · Dec 19, 2019Immunology