R. Dong

Dynamic Localization of Leukemia Stem Cells via CXCL12 Regulates Leukemia Progression

This study shows that the CXCL12 gradient, regulated by DPP4 and GPC3, determines leukemia stem cell (LSC) localization and behavior, influencing leukemia progression.

RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

This study identifies ArcZ as a small RNA inhibitor of capsular hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through RNA interactome profiling.

HNF&alpha is a target of the Wnt/beta-catenin pathway and regulates colorectal carcinogenesis

This study shows HNF4 is upregulated in colorectal cancer and promotes tumorigenesis by being activated by the Wnt/β-catenin pathway.

Nodulation Trio in Medicago truncatula: Unveiling the Overlapping Roles of MtLYK2, MtLYK3, and MtLYK2bis

This study investigates the roles of MtLYK2, MtLYK3, and MtLYK2bis in Medicago truncatula nodulation using CRISPR/Cas mutants, finding redundant functions and suggesting a one-receptor model with multiple specificities.

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

The mitochondrial deoxyguanosine kinase is required for female fertility in mice

This study shows that Dguok knockout causes female infertility in mice by impairing ovarian development, oocyte maturation, and mitochondrial function.

A Biologically Plausible Spiking Neural Network for Decoding Kinematics in the Hippocampus and Premotor Cortex

This paper develops a spiking neural network for decoding kinematics from neural data, achieving high correlation with true data and outperforming alternative methods.

Depletion of collagen IX alpha2 interferes osteochondral homeostasis of the knee joint which ultimately causing osteoarthritis-like articular cartilage damage

This study shows that Col92 deficiency in mice leads to osteochondral homeostasis disruption and osteoarthritis-like cartilage damage in the knee joint.

Tight nanoscale clustering of Fc gamma-receptors using DNA origami promotes phagocytosis

The paper shows that tightly clustering Fc gamma-receptors using DNA origami enhances phagocytosis by increasing receptor phosphorylation and downstream signaling efficiency.

DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation

The paper uses DNA origami to pattern synthetic T cell receptors and shows how spatial arrangement affects signaling sensitivity and kinetics.

Design of proteins presenting discontinuous functional sites using deep learning

This paper designs proteins with discontinuous functional sites using deep learning, eliminating the need for pre-defined secondary structures and enabling diverse scaffold generation.

Electronic blood vessel

This paper develops an electronic blood vessel using flexible bio-degradable circuitry to enhance endothelization and enable gene delivery, showing good biocompatibility and patency in a rabbit model.

Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)

This study shows CAR T cells bypass LAT for some signaling outputs but still require it for IL-2 production, revealing a rewired signaling pathway.

Establishment of the trans-resveratrol-induced mouse pulmonary fibrosis model and its comparison with the bleomycin-induced model

This study establishes a trans-resveratrol-induced mouse pulmonary fibrosis model and compares it to the bleomycin-induced model, finding it causes less damage and progresses more slowly.

Gradual decrease in the inter-population diversity of HIV-1 Env among group M lineages worldwide

The paper analyzes the evolution of HIV-1 Env diversity across clades and regions, finding that inter-population diversity decreases while intra-population diversity increases due to conserved selective pressures.

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma

This study develops a 5-hydroxymethylcytosine (5hmC) diagnostic model from circulating cell-free DNA to detect hepatocellular carcinoma with high accuracy and prognostic value.