Author

F. Blaeschke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Marson· 4 shared R. Schmidt· 2 shared T. Feuchtinger· 2 shared T. L. Roth· 2 shared A. Kirschner· 1 shared A. Marchetto· 1 shared A. N. Akatli· 1 shared A. To· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersImmunology

A. Marson

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Author profile →

5 papers

Recent·Most cited

Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

F. Blaeschke, Y. Y. Chen, R. Apathy, Z. Li, C. T. Mowery, W. A. Nyberg, A. To, R. Yu, R. Bueno, M. C. Kim, R. Schmidt, D. B. Goodman, T. Feuchtinger, J. Eyquem, C. J. Ye, , A. Marson

The paper develops ModPoKI, a platform for modular construction of DNA knockin libraries to identify gene constructs that enhance T cell function and persistence.

bioRxiv · Jul 27, 2022Immunology

CRISPR activation and interference screens in primary human T cells decode cytokine regulation

R. Schmidt, Z. Steinhart, M. Layeghi, J. W. Freimer, V. Q. Nguyen, F. Blaeschke, A. Marson

The paper uses CRISPR activation and interference screens in primary human T cells to identify cytokine regulators, finding genes like FOXQ1 that influence cytokine production and immune cell functions.

bioRxiv · May 11, 2021Immunology

TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers

R. L. Rutishauser, C. D. T. Deguit, J. Hiatt, F. Blaeschke, T. L. Roth, L. Wang, K. Raymond, C. E. Starke, J. C. Mudd, W. Chen, C. Smullin, R. Matus-Nicodemos, R. Hoh, M. Krone, F. M. Hecht, , P. W. Hunt

The paper shows TCF-1 enhances HIV-specific CD8+ T cell expansion and memory properties in elite controllers.

bioRxiv · Jan 7, 2020 · PreprintImmunology

Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)

R. Dong, K. A. Libby, F. Blaeschke, A. Marson, R. D. Vale, X. Su

This study shows CAR T cells bypass LAT for some signaling outputs but still require it for IL-2 production, revealing a rewired signaling pathway.

bioRxiv · Dec 19, 2019Immunology

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

M. C. Baldauf, J. S. Gerke, A. Kirschner, F. Blaeschke, M. Effenberger, K. Schober, R. Alba Rubio, T. Kanaseki, M. M. Kiran, M. Dallmayer, J. Musa, N. Akpolat, A. N. Akatli, F. C. Rosman, O. Ozen, , T. G. Grunewald

The paper introduces RAVEN, a software tool that identifies cancer-specific genes encoding MHC-affine peptides from gene expression data, validated across 50 cancer types.

bioRxiv · Sep 24, 2017Immunology