Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates
R. L. Wilson, J. Kropp Schmidt, B. N. Davenport, E. Ren, L. T. Keding, S. Shaw, M. L. Schotzko, K. Antony, H. A. Simmons, T. Golos, H. Jones
This study evaluates maternal, placental, and fetal responses to non-viral nanoparticle-mediated IGF1 gene therapy in nonhuman primates, finding no adverse effects and placental signaling changes indicating homeostasis maintenance.
bioRxiv · Jun 16, 2023 · PreprintPhysiology