H. Jones

Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque

This study delivers hIGF1-loaded nanoparticles to the placenta of a pregnant rhesus macaque via uterine artery catheterization, showing successful placental uptake and expression of hIGF1.

Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model

This paper demonstrates that placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model by improving fetal weight, blood glucose, and reducing cortisol levels.

Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates

This study evaluates maternal, placental, and fetal responses to non-viral nanoparticle-mediated IGF1 gene therapy in nonhuman primates, finding no adverse effects and placental signaling changes indicating homeostasis maintenance.

Nutritional and genetic variations within foxtail millet (Setaria italica) landraces collected from indigenous communities across the Philippines

This study analyzes nutritional value and genetic diversity of foxtail millet landraces from the Philippines, finding high zinc and iron content in some accessions and modest genetic diversity with two unadmixed groups.

Effect of soilless media on small-scale propagation of Pinguicula gigantea

This study evaluates the effect of soilless media on leaf production in Pinguicula gigantea, finding that soil type significantly impacts leaf number but not biomass or plantlet diameter.

Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua

This study shows that hIGF-1 nanoparticle treatment differentially affects vascular remodeling factors in guinea pig sub-placenta/decidua under FGR and normal conditions.

Placental nanoparticle gene therapy normalizes gene expression changes in the fetal liver associated with fetal growth restriction in a fetal sex-specific manner

This study shows that placental nanoparticle gene therapy with hIGF-1 reduces sex-specific gene expression changes in fetal livers of growth-restricted fetuses.

Replicative ageing perturbs the metabolic signature of murine C2C12 skeletal myotubes

This study examines how replicative ageing affects metabolic profiles in murine C2C12 myotubes, finding reduced mitochondrial efficiency and altered amino acid metabolism.

(--)-Epicatechin alters reactive oxygen and nitrogen species production independent of mitochondrial respiration in human vascular endothelial cells

Nanoparticle-mediated transgene expression of insulin-like growth factor 1 in the growth restricted guinea pig placenta increases placenta nutrient transporter expression and fetal glucose concentrations

This study uses nanoparticle-mediated hIGF-1 gene therapy in a guinea pig model of FGR to increase placental nutrient transporter expression and fetal glucose concentrations.

Characterization of methylation profiles in spontaneous preterm birth placental villous tissue

This study identifies DNA methylation profiles in placental tissue from spontaneous preterm births, finding molecular hypermaturity and similarities to term birth samples.

ABPP-HT - high-throughput activity-based profiling of deubiquitylating enzyme inhibitors in a cellular context

This paper introduces ABPP-HT, a high-throughput method for assessing DUB inhibitor selectivity in cells, showing improved efficiency over traditional ABPP.

Test Agreement Between Roche Cobas 6800 and Cepheid GeneXpert Xpress SARS-CoV-2 Assays at High Cycle Threshold Ranges

This study compares the agreement between Roche Cobas 6800 and Cepheid GeneXpert Xpress SARS-CoV-2 assays at high cycle threshold values, finding close agreement despite high variability.

Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift

This paper demonstrates that quantifying the fluorescence red edge excitation shift (REES) can sensitively monitor monoclonal antibody stability across timeframes and concentrations.

Effects of breeding history and crop management on the root architecture of wheat

This study examines how breeding history and crop management affect wheat root architecture, finding that modern varieties have fewer roots than historic ones and that management practices influence root traits depending on genotype.

The geography of the Anthropocene differs between the land and the sea

The paper examines geographic differences in anthropogenic drivers of biodiversity change between land and sea, identifying distinct threat complexes with varying driver intensities.

Curriculum-based outdoor learning for children aged 9-11: A qualitative analysis of pupils' and teachers' views.

This study explores the views of pupils and teachers on an outdoor learning program for children aged 9-11, finding benefits for engagement, behavior, and wellbeing, but noting barriers like testing demands and safety concerns.