S. Shaw

getphylo: rapid and automatic generation of multi-locus phylogenetic trees

getphylo automatically generates multi-locus phylogenetic trees from GenBank files, offering faster and more flexible analysis than existing tools.

The genomic signature and transcriptional response of metal tolerance in brown trout inhabiting metal-polluted rivers

This study investigates the genomic and transcriptomic signatures of metal tolerance in brown trout from metal-polluted rivers, identifying genetic and gene expression changes associated with metal resistance.

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4+ T cell mediated resistance to Cryptosporidium

The paper investigates the role of intestinal cDC1s in CD4+ T cell-mediated resistance to Cryptosporidium, showing they support T cell expansion and effector function through IL-12-dependent and -independent mechanisms.

Genetic crosses within and between species of Cryptosporidium

This paper demonstrates genetic crosses within and between Cryptosporidium species, showing genomic recombination and its implications for parasite adaptation and host specificity.

A host AAA-ATPase exhibits bacteriolytic activity for clearance of microbial infection

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.

Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates

This study evaluates maternal, placental, and fetal responses to non-viral nanoparticle-mediated IGF1 gene therapy in nonhuman primates, finding no adverse effects and placental signaling changes indicating homeostasis maintenance.

Candida auris undergoes adhesin-dependent and -independent cellular aggregation

This paper identifies two types of cellular aggregation in Candida auris, one linked to antifungal treatment and another dependent on growth conditions and an ALS-family adhesin, with implications for immune evasion and virulence.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

Distribution, organization and expression of genes concerned with anaerobic lactate-utilization in human intestinal bacteria

This study identifies gene clusters involved in lactate utilization in two human gut bacteria, revealing distinct pathways and regulatory mechanisms.

Crosstalk between enterocytes and innate lymphoid cells drives early IFN-g-mediated control of Cryptosporidium

This study shows enterocytes promote ILC production of IFN-gamma, which restricts Cryptosporidium growth by acting on enterocytes themselves.

Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes

This study shows that African trypanosomes use pH gradients mediated by cyclic AMP signalling and glucose metabolism for taxis, with implications for their infection establishment.

Domestication of Campylobacter jejuni NCTC 11168

This study compares genetic and phenotypic variation in 23 isolates of the reference Campylobacter jejuni strain NCTC 11168, showing significant genomic and phenotypic differences despite being considered identical.

High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth

This study identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth through a high-throughput screen and characterizes their mechanisms of action.