ImmunologybioRxiv
The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus
T. M. Li, V. Zyulina, E. S. Seltzer…·T. T. Lu
This study shows that IFN-I in lupus skin reduces Langerhans cell ADAM17 activity, leading to increased photosensitivity, and that anti-IFNAR treatment restores ADAM17 function and reduces photosensitivity.