Author

K. Borrelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

G. Skiniotis· 2 shared M. J. Robertson· 2 shared A. Heliou· 1 shared B. M. Hudson· 1 shared D. A. Keedy· 1 shared G. C. P. van Zundert· 1 shared G. C. van Zundert· 1 shared H. van den Bedem· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

G. Skiniotis

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Author profile →

3 papers

Recent·Most cited

Plasticity in Ligand Recognition at Somatostatin Receptors

M. J. Robertson, J. G. Meyerowitz, O. Panova, K. Borrelli, G. Skiniotis

The paper presents cryo-EM structures of SSTR2 with ligands and Gi protein, revealing ligand recognition mechanisms and subtype selectivity.

bioRxiv · Nov 2, 2021Biophysics

GemSpot: A Pipeline for Robust Modeling of Ligands into CryoEM Maps

M. J. Robertson, G. C. P. van Zundert, K. Borrelli, G. Skiniotis

GemSpot models ligand poses into cryoEM maps using computational chemistry methods, achieving accurate interactions and map agreement in validated cases.

bioRxiv · Sep 3, 2019Biophysics

qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

G. C. van Zundert, B. M. Hudson, D. A. Keedy, R. Fonseca, A. Heliou, P. Suresh, K. Borrelli, T. Day, J. S. Fraser, H. van den Bedem

qFit-ligand identifies unmodeled ligand conformations in crystal structures, revealing 29% of drug-like molecules exhibit conformational heterogeneity that could improve drug design.

bioRxiv · Jan 25, 2018Biophysics