R. Fonseca

Targeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma

This study identifies DNA2 as a key factor in mitochondrial metabolism that enables multiple myeloma cells to survive DNA damage, showing that targeting DNA2 overcomes metabolic reprogramming and enhances therapy effectiveness.

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

This study identifies distinct epigenetic trajectories in CD8+ T cells during acute infection, revealing how chromatin accessibility changes guide the development of tissue-resident memory T cells versus circulating memory T cells.

Differential Cetacea Circadian Rhythmicity is associated with the molecular erosion of Cortistatin

The paper examines the molecular changes in Cortistatin across 139 mammalian genomes, finding that cetaceans and other mammals with atypical biorhythms have accumulated deleterious mutations in CORT.

Uncovering patterns of atomic interactions in static and dynamic structures of proteins

The paper develops tools for analyzing interatomic interactions in protein structures and simulations, creating a web resource to identify functional interaction patterns in GPCRs, G proteins, kinases, and muscarinic receptors.

qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

qFit-ligand identifies unmodeled ligand conformations in crystal structures, revealing 29% of drug-like molecules exhibit conformational heterogeneity that could improve drug design.