Author

O. Panova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 4 Research Focus:protein structure prediction· 3 Organism:human· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

G. Skiniotis· 4 shared A. B. Seven· 3 shared F. He· 2 shared G. Eskici· 2 shared J. G. Meyerowitz· 2 shared M. J. Robertson· 2 shared M. M. Papasergi-Scott· 2 shared Y. Gao· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiophysics

G. Skiniotis

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Author profile →

4 papers

Recent·Most cited

Time-resolved cryo-EM of G protein activation by a GPCR

M. M. Papasergi-Scott, G. Perez-Hernandez, H. Batebi, Y. Gao, G. Eskici, A. B. Seven, O. Panova, D. Hilger, M. Casiraghi, F. He, L. Maul, P. Gmeiner, B. K. Kobilka, P. W. Hildebrand, G. Skiniotis

This study uses time-resolved cryo-EM to visualize the conformational changes in a GPCR-G protein complex during activation, revealing the structural pathway of G protein dissociation.

bioRxiv · Mar 20, 2023Pharmacology & Toxicology

Plasticity in Ligand Recognition at Somatostatin Receptors

M. J. Robertson, J. G. Meyerowitz, O. Panova, K. Borrelli, G. Skiniotis

The paper presents cryo-EM structures of SSTR2 with ligands and Gi protein, revealing ligand recognition mechanisms and subtype selectivity.

bioRxiv · Nov 2, 2021Biophysics

Structure Determination of Inactive-State GPCRs with a Universal Nanobody

M. J. Robertson, M. M. Papasergi-Scott, F. He, A. B. Seven, J. G. Meyerowitz, O. Panova, M.-C. Peroto, T. Che, G. Skiniotis

This paper uses nanobodies to determine cryo-EM structures of inactive-state GPCRs, achieving resolutions comparable to X-ray crystallography and providing insights into ligand binding.

bioRxiv · Nov 2, 2021Biophysics

Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6

Y. Gao, G. Eskici, S. Ramachandran, F. Poitevin, A. B. Seven, O. Panova, G. Skiniotis, R. A. Cerione

The paper reports a cryoEM structure of the PDE6 complex with GTP-bound transducin, revealing its catalytic mechanism and conformational dynamics.

bioRxiv · Apr 1, 2020Biophysics