BiochemistrybioRxiv
Self-assembly of mutant huntingtin exon-1 fragments into large complex fibrillar structures involves nucleated branching
A. S. Wagner, A. Z. Politi, A. Ast…·E. E. Wanker
This study investigates the self-assembly of mutant huntingtin exon-1 fragments into complex fibrillar structures, identifying two nucleation mechanisms and their role in fibril formation.
DOI 10.1016/j.jmb.2018.03.017