Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic
K. He, E. Song, S. Upadhyayula, S. Dang, R. Gaudin, W. Skillern, K. Bu, B. R. Capraro, I. Rapoport, I. Kusters, M. Ma, T. Kirchhausen
The paper shows Aux1 and GAK are recruited in transient bursts to clathrin-coated vesicles, with their timing linked to phosphoinositide changes, suggesting a lipid-switch mechanism for uncoating.
bioRxiv · Jul 30, 2019Cell Biology