K. He

An engineered prodrug selectively suppresses β-lactam resistant bacteria in a mixed microbial setting

This paper engineers a prodrug that selectively suppresses β-lactam-resistant bacteria in mixed cultures by exploiting ESBL activity.

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Functional Analysis of the Zinc Finger Modules of the S. cerevisiae Splicing Factor Luc7

This study investigates the role of zinc finger domains in the yeast splicing factor Luc7 using humanized variants, revealing their impact on splice site selection and interactions with Prp28.

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

This study identifies USP8's role in endosome maturation by mediating Rab5-to-Rab7 switch through recruitment by Rabex5 and promotion of SAND-1/Mon1 recruitment.

Pharmacologically inducing regenerative cardiac cells by small molecule drugs

This study shows that a two-drug combination induces regenerative cardiac cells from cardiomyocytes in vitro and in vivo, improving heart function after injury.

Formin tails act as a switch, inhibiting or enhancing processive actin elongation

The paper investigates how tail domains in formins regulate actin assembly through alternative splicing, showing that some tails inhibit processive elongation while others enhance it.

Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps

This study simulates the feeding and respiration of early Cambrian cnidarian polyps using CFD to show how muscle contractions drive water flow, supporting hypotheses about ancestral medusozoan behavior.

An uncanonical CDK6 activity inhibits cilia function by suppressing axoneme polyglutamylation

This study identifies CDK6 as a regulator of axoneme polyglutamylation by phosphorylating FIP5, leading to impaired cilia function and ciliopathies, and shows CDK6 inhibitors can restore cilia function.

The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

This study identifies apicoplast transporters in Toxoplasma gondii using TurboID and genome engineering, showing AMT1 and AMT2 are critical for parasite growth and virulence.

Deciphering deep-sea chemosynthetic symbiosis by single-nucleus RNA-sequencing

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

Genetic excision of the regulatory cardiac troponin I extension in high heart rate mammal clades

The paper shows that genetic excision of a cardiac troponin I extension in mammals allows for high heart rates by mimicking phosphorylation without adrenergic stimulation.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

Single-cell transcriptomic analyses reveal the cellular and genetic basis of aquatic locomotion in scyphozoan jellyfish

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

The soil emergence-related transcription factor PIF3 regulates root penetration by interacting with the receptor kinase FER

This study shows that PIF3, a transcription factor, regulates root penetration in Arabidopsis by interacting with FER, a receptor kinase, and modulating mechanosensitive ion channels and root cap cell sloughing.

Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world smallest mammalian divers

The paper uses myoglobin primary structure to identify convergent transitions to semi-aquatic life in Eulipotyphla mammals.

PCV2 aggravated SS2 infection directly showed from differentially expressed proteome of PK15 cells.

The paper shows PCV2 worsens SS2 infection in PK15 cells through differentially expressed proteins and pathway analysis.

Blimp-1 is essential for Th2 cell development and allergic asthma

This study identifies Blimp-1 as a positive regulator of Th2 cell development and allergic asthma through an IL-10-STAT3-Blimp-1 circuit.

Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic

The paper shows Aux1 and GAK are recruited in transient bursts to clathrin-coated vesicles, with their timing linked to phosphoinositide changes, suggesting a lipid-switch mechanism for uncoating.

Cryptic phylogeographic history sheds light on the generation of species diversity in sky-island mountains

This study uses phylogeographic analysis of the long-tailed mole to reveal how complex topography and climate stability in Chinese sky islands drive genetic divergence and species diversification.