Author

S. Dang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 4 Ecology· 2 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Research Focus:cell signaling & trafficking· 4 Assay:cryo-EM· 4 Organism:human· 3 Research Focus:protein structure prediction· 3 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

K. He· 4 shared Y. Du· 3 shared Y. Wang· 3 shared D. Li· 2 shared H. Goldsmith· 2 shared H. Rosenthal· 2 shared K. St Fleur· 2 shared L. C. Harrington· 2 shared

Activity by Year

2018-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersCell Biology

K. He

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12 papers

Recent·Most cited

Logic-based modeling of biological networks with Netflux

A. P. Clark, M. Chowkwale, A. Paap, S. Dang, J. J. Saucerman

The paper introduces Netflux, a user-friendly tool for simulating biological networks without programming, and provides a tutorial on its use for modeling and perturbation analysis.

PLOS Computational Biology · Apr 4, 2025Peer-reviewedBioengineering

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

J. Xu, Y. Liang, N. Li, S. Dang, A. Jiang, Y. Liu, Y. Guo, X. Yang, Y. Yuan, X. Zhang, Y. Yang, Y. Du, A. Shi, X. Liu, D. Li, K. He

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

bioRxiv · Jul 9, 2024Cell Biology

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

J. Wang, Z. An, Z. Wu, W. Zhou, P. Sun, P. Wu, R. Xue, S. Dang, X. Bai, W. Wang, R. Chen, Y. Du, P. Huang, S. M. Lam, Y. Ai, , K. He

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

bioRxiv · Jul 5, 2024Cell Biology

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

Y. Miao, Y. Du, B. Wang, J. Liang, Y. Liang, S. Dang, J. Liu, D. Li, K. He, M. Ding

This study identifies USP8's role in endosome maturation by mediating Rab5-to-Rab7 switch through recruitment by Rabex5 and promotion of SAND-1/Mon1 recruitment.

bioRxiv · Jan 10, 2024Cell Biology

Cryo-EM structure of TMEM63C suggests it functions as a monomer

Y. Qin, D. Yu, D. Wu, J. Dong, W. T. Li, C. Ye, K. C. Cheung, Y. Zhang, Y. Xu, Y. Wang, Y. S. Shi, S. Dang

The paper determines the cryo-EM structure of mouse TMEM63C, reveals structural differences from plant orthologues, and shows TMEM63C functions as a monomer while TMEM63B is a mix of monomer and dimer.

bioRxiv · Jul 4, 2023Biophysics

Structural study of membrane proteins using vesicles

H. Liu, S. Dang

This study develops a vesicle-based method to determine membrane protein structures in their native lipid environment, demonstrating it with the AcrB transporter and showing a different assembly state compared to detergent-solubilized forms.

bioRxiv · Jun 17, 2023Biophysics

Metallo-Supramolecular Branched Polymer Protects Particles from Air-water Interface in Single-Particle Cryo-Electron Microscopy

Y. Xu, Y. Qin, L. Wang, Y. Zhang, Y. Wang, S. Dang

This study introduces a metallo-supramolecular branched polymer to improve particle distribution in single-particle cryo-EM by preventing air-water interface damage and preferred orientation.

bioRxiv · Jun 8, 2022Biophysics

Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system

F. Zhao, X. Lin, K. Cai, Y. Jiang, T. Ni, Y. Chen, J. Feng, S. Dang, C.-Z. Zhou, Q. Zeng

This study shows that cyanophage PstS enhances host phosphate uptake and forms a chimeric ABC transporter with host proteins.

bioRxiv · Jul 20, 2021 · PreprintMicrobiology

The effects of host availability and fitness on Aedes albopictus blood feeding patterns in New York

K. M. Fikrig, E. Martin, S. Dang, K. St Fleur, H. Goldsmith, S. Qu, H. Rosenthal, S. Pitcher, L. C. Harrington

This study examines Ae. albopictus blood feeding patterns in New York, finding that cats and dogs are disproportionately fed upon compared to humans, with no significant fitness differences among hosts.

bioRxiv · May 13, 2021Ecology

Sugar feeding patterns of New York Aedes albopictus mosquitoes are affected by environmental dryness, flowers, and host seeking

K. Fikrig, S. Peck, P. Deckerman, S. Dang, K. St Fleur, H. Goldsmith, S. Qu, H. Rosenthal, L. C. Harrington

This study examines sugar feeding patterns of Aedes albopictus mosquitoes in the Northeastern US, finding that environmental dryness, flower presence, and host seeking behavior influence sugar feeding rates.

bioRxiv · Mar 26, 2020Ecology

Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic

K. He, E. Song, S. Upadhyayula, S. Dang, R. Gaudin, W. Skillern, K. Bu, B. R. Capraro, I. Rapoport, I. Kusters, M. Ma, T. Kirchhausen

The paper shows Aux1 and GAK are recruited in transient bursts to clathrin-coated vesicles, with their timing linked to phosphoinositide changes, suggesting a lipid-switch mechanism for uncoating.

bioRxiv · Jul 30, 2019Cell Biology

Structural insight into TRPV5 channel function and modulation

S. Dang, M. K. van Goor, Y. Wang, D. Julius, Y. Cheng, J. van der Wijst

The paper presents cryo-EM structures of TRPV5 and its mutants, revealing structural features that explain its calcium selectivity and functional differences from other TRPV channels.

bioRxiv · Oct 4, 2018Biophysics