E. Song

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

Setdb1-loss induces type-I interferons and immune clearance of melanoma

This study identifies Setdb1 loss as a driver of type-I interferon signaling and immune clearance of melanoma through ERV activation and CD8+ T-cell infiltration.

Effects of hydroxychloroquine on atrial electrophysiology in in silico wild-type and PITX2+/- atrial cardiomyocytes

This study uses a computational model to examine how hydroxychloroquine affects atrial electrophysiology in wild-type and PITX2+/- atrial cardiomyocytes, finding no significant arrhythmogenic effects at therapeutic concentrations but potential risks at higher doses.

A novel pathway of functional microRNA uptake and mitochondria delivery

The paper identifies RNA phase separation as a novel pathway for extracellular miRNA uptake and shows that these miRNAs are delivered to mitochondria via PNPT1.

The evolutionary trajectory of drosophilid walking

This study analyzes the evolution of walking in drosophilid species, finding that movement patterns are conserved in a universal behavior space but evolve rapidly in their temporal structure.

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.

Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2

The paper investigates the roles of humoral and cellular immunity in SARS-CoV-2 clearance and protection against a variant, finding antibodies mediate protection in both vaccinated and naturally infected mice.

Stepwise transmigration cascade of T and B cells through the perivascular channel in lymph node high endothelial venules

This study uses intravital imaging to show T and B cells migrate through HEVs via distinct post-luminal steps involving ECs and FRCs, with T and B cells sharing trans-FRC hot spots but not trans-EC ones.

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

Neuroinvasion of SARS-CoV-2 in human and mouse brain

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

This paper develops a mouse model of SARS-CoV-2 using AAV-mediated hACE2 expression, showing type I interferons fail to control viral replication and drive pathology.

PD-1 blockade-driven anti-tumor CD8+ T cell immunity requires XCR1+ dendritic cells

This study shows that XCR1+ dendritic cells are essential for PD-1 immunotherapy to activate CD8+ T cells and control tumors in mice and humans.

The combination of lipopolysaccharide and D-galactosamine administration show positive genotoxic effect in mice liver

This study shows that LPS/D-GalN co-administration causes DNA damage in liver cells, with chronic exposure also affecting brain cells, suggesting genotoxic potential.

CRISPR-based bioengineering of the Transferrin Receptor revealed a role for Rab7 in the biosynthetic secretory pathway

The paper uses CRISPR-based bioengineering to study TfR trafficking and identifies Rab7 as an intermediate compartment in the Golgi-to-PM transport of neosynthetic TfR.

Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression

The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.

Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic

The paper shows Aux1 and GAK are recruited in transient bursts to clathrin-coated vesicles, with their timing linked to phosphoinositide changes, suggesting a lipid-switch mechanism for uncoating.

Probabilistic Models of Larval Zebrafish Behavior: Structure on Many Scales

This study models larval zebrafish behavior using probabilistic frameworks to understand how hunger state and environmental factors influence action selection during exploration and hunting.