Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells
K. M. Gao, K. Nundel, K. Chiang, X. Yin, P. J. Utz, K. A. Fitzgerald, A. Marshak-Rothstein
This study shows that STING V154M mutation in non-hematopoietic cells activates autoreactive lymphocytes, leading to autoantibodies and lung inflammation in mice, mirroring SAVI in humans.
bioRxiv · Jul 28, 2023 · PreprintImmunology