Hematological and Neurological Expressed 1 (HN1): a predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.
N. W. Bateman, P.-n. Teng, E. Hope, B. Hood, J. Oliver, W. Ao, M. Zhou, G. Wang, D. Tommarello, K. Wilson, K. A. Conrads, C. A. Hamilton, K. Darcy, Y. Casablanca, G. L. Maxwell, , T. P. Conrads
This study identifies HN1 as a predictive and pharmacodynamic biomarker of metformin response in endometrioid endometrial cancer, showing it is elevated in responders and decreases after treatment.
bioRxiv · Apr 9, 2019 · PreprintCancer Biology