J. Oliver

Emergence of a senescent and inflammatory pulmonary CD4+ T cell population prior to lung allograft failure

The paper identifies CD4+CD57+PD1+ T cells in lung transplant recipients that predict allograft dysfunction and are associated with fibrosis in both human and mouse models.

Tick extracellular vesicles alter keratinocyte function in the skin epidermis

This study shows that tick extracellular vesicles alter keratinocyte function in the epidermis by inhibiting proliferation and wound closure, linked to phosphoinositide 3-kinase, KGF-1, and TGF-β.

A transmission chain linking Mycobacterium ulcerans with Aedes notoscriptus mosquitoes, possums and human Buruli ulcer cases in southeastern Australia

The paper investigates the transmission chain of Mycobacterium ulcerans between mosquitoes, possums, and humans in southeastern Australia, finding a significant association between M. ulcerans and Aedes notoscriptus mosquitoes.

Perfluorooctanoic Acid Induces Liver and Serum Dyslipidemia in Humanized PPARα Mice Fed an American Diet

This study shows PFOA affects lipid levels in hPPAR mice on an American diet, with context-dependent effects on liver and serum triglycerides.

Extensive Intratumor Proteogenomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens

The paper analyzes proteogenomic heterogeneity in ovarian tumors using multiregion sampling and reveals distinct expression patterns between tumor epithelium and stroma.

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

Duplications drive diversity in Bordetella pertussis on an underestimated scale.

This study identifies widespread tandem duplications in B. pertussis genomes using read depth analysis, revealing 272 putative duplications across 11 hotspots and highlighting genome instability.

Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet

This study shows PFOA exposure increases liver mass and alters cholesterol-related gene expression in hPPAR mice fed an American diet.

VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin

The paper shows VE-PTP prevents autophagic degradation of VE-cadherin in VM+ tumor cells, supporting VM formation.

Hematological and Neurological Expressed 1 (HN1): a predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.

This study identifies HN1 as a predictive and pharmacodynamic biomarker of metformin response in endometrioid endometrial cancer, showing it is elevated in responders and decreases after treatment.