K. Wilson

Polycaprolactone-based shape memory foams as self-fitting vaginal stents

This paper develops a self-fitting vaginal stent using shape-memory polymer foams that expand at body temperature to prevent vaginal stenosis, demonstrating effective shape recovery and retention in a simulated model.

Combining in vivo and in vitro approaches to better understand host-pathogen interactions

This study combines in vivo and in vitro approaches to show that host nutrition primarily affects bacterial growth in a host-parasite system, rather than host immune responses.

Nutribloods: novel synthetic lepidopteran haemolymphs for understanding insect-microbe interactions in vitro

The paper introduces synthetic haemolymphs (nutribloods) to study how nutrient profiles affect microbial growth in insect-pathogen interactions.

Tobacco Smoke Exposure is Characterized by a Distinct Nasal Rhinotype in a Pediatric Population

The paper examines the impact of secondhand tobacco smoke exposure on the nasal microbiome in children, finding a distinct microbial rhinotype associated with higher cotinine levels.

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead

This paper introduces CMX990, a potent SARS-CoV-2 3CL protease inhibitor with improved potency and clearance compared to nirmatrelvir, advancing to Phase 1 clinical trials.

Fawn bedsite selection by a large ungulate living in a peri-urban area

This study examines how female fallow deer select birthing sites in response to human and dog presence in an urban park, finding they avoid high-traffic areas and prefer dense vegetation.

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

The paper develops brain region-specific neural spheroids for disease modeling and drug screening, demonstrating their utility in Alzheimer's, Parkinson's, and Opioid Use Disorder.

Long-term temporal trends in gastrointestinal parasite infection in wild Soay sheep

This study examines 31-year trends in gastrointestinal parasite prevalence and abundance in wild Soay sheep, finding independent effects of host density and year on parasite dynamics.

Evaluation of PRKACA as a Therapeutic Target for Fibrolamellar Carcinoma

This study evaluates PRKACA as a therapeutic target for fibrolamellar carcinoma using PDX models and shows that its knockdown or inhibition reduces tumor growth.

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

This study identifies how oncogenic RAS activates mTORC1 in multiple myeloma by co-opting amino acid sensing pathways through a novel signaling complex.

Rapid spread of a symbiotic virus in a major crop pest following wide-scale adoption of Bt-cotton in China

The paper shows that Bt-cotton adoption in China increased the prevalence of a symbiotic virus in the cotton bollworm, enhancing its resistance to Bt-cotton.

Evaluating institutional open access performance: Methodology, challenges and assessment

The paper evaluates open access performance across 1,207 institutions globally, showing progress and highlighting regional differences in open access strategies.

Evaluating institutional open access performance: Sensitivity analysis

The paper evaluates how sensitive institutional open access performance metrics are to data source choices and versions, highlighting the need for transparency in methodology.

Keeping it clean: the cell culture quality control experience at the National Center for Advancing Translational Sciences

The paper describes NCATS's implementation of mycoplasma and STR testing to improve cell line quality, reducing contamination and misidentification in translational research.

Comparison of bibliographic data sources: Implications for the robustness of university rankings

This study compares bibliographic data sources to assess their impact on university rankings, finding significant differences in metadata and rankings based on the source used.

A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in Drosophila melanogaster

This study shows that the insulin-like signaling pathway influences uric acid metabolism in Drosophila, with conserved effects in humans, and identifies potential therapeutic targets for gout and kidney stones.

Hematological and Neurological Expressed 1 (HN1): a predictive and pharmacodynamic biomarker of metformin response in endometrial cancers.

This study identifies HN1 as a predictive and pharmacodynamic biomarker of metformin response in endometrioid endometrial cancer, showing it is elevated in responders and decreases after treatment.

Macronutrients modulate resistance to infection and immunity in Drosophila

This study shows that Drosophila infected with M. luteus reduce protein intake and increase carbohydrate intake, improving survival through nutritional self-medication.

Comparison of microbiome and culture techniques for determination of gastrointestinal microbial communities in ceca of chickens

This study compares culture-based and NGS methods for quantifying microbial communities in chicken ceca, finding that CFU and NGS results diverge over time with no strong correlation.

Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages

This paper uses untargeted mass spectrometry to analyze chemical changes in foods during preparation and storage, finding that some processes alter molecular composition while others primarily involve extraction.

Detecting Drug-Target Binding In Cells Using Fluorescence Activated Cell Sorting Coupled With Mass Spectrometry Analysis

This paper introduces a new method called TAPS to assess drug-target binding in cells, demonstrating its effectiveness with the challenging KMO target.