Repeated hypoglycemia blunts the responsiveness of glucose-inhibited GHRH neurons by remodeling neural inputs and disrupting mitochondrial structure and function.
M. Bayne, A. Alvarsson, K. Devarakonda, R. Li, M. Jimenez-Gonzalez, K. Conner, M. Varghese, M. N. Serasinghe, J. E. Chipuk, P. R. Hof, S. A. Stanley
This study shows repeated hypoglycemia reduces GHRH neuron responsiveness by altering neural inputs and mitochondrial function, suggesting mitochondrial dynamics as a target for preventing hypoglycemia unawareness.
bioRxiv · Oct 3, 2019Physiology