BiophysicsbioRxiv
Directed inter-domain motions enable the IsdH Staphylococcus aureus receptor to rapidly extract heme from human hemoglobin
J. Clayton, K. Ellis-Guardiola, B. Mahoney…·J. Wereszczynski
This study shows directed inter-domain motions in the IsdH receptor enable efficient heme extraction from human hemoglobin by distorting the heme pocket.
DOI 10.1016/j.jmb.2022.167623