Author

K. Hess

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:machine learning (classical)· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

A. Lopes· 2 shared A. M. Hayward· 2 shared D. Reker· 2 shared G. Traverso· 2 shared K. Ishida· 2 shared A. Gardner· 1 shared A. Lytoon-Jean· 1 shared A. R. Kirtane· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

A. Lopes

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A machine learning liver-on-a-chip system for safer drug formulation

Y. Shi, C.-H. Lin, D. Reker, C. Steiger, K. Hess, J. E. Collins, S. Tamang, K. Ishida, A. Lopes, J. Wainer, A. M. Hayward, C. Walesky, W. Goessling, G. Traverso

This paper develops a liver-on-a-chip system combined with machine learning to model drug metabolism and identify excipients that reduce hepatotoxicity in vivo.

bioRxiv · Sep 5, 2022 · PreprintBioengineering

Computationally guided high-throughput design of self-assembling drug nanoparticles

D. Reker, Y. Rybakova, A. R. Kirtane, R. Cao, J. W. Yang, N. Navamajiti, A. Gardner, R. M. Zhang, T. Esfandiary, J. L'Heureux, T. von Erlach, E. M. Smekalova, D. Leboeuf, K. Hess, A. Lopes, , G. Traverso

This paper develops a high-throughput screening platform with machine learning to design self-assembling drug nanoparticles, identifying 101 novel formulations from 2.1 million combinations.

bioRxiv · Sep 30, 2019Bioengineering

The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63

P. A. Sandoz, R. A. Denhardt-Eriksson, L. Abrami, L. Abriata, G. Spreemann, C. Maclachlan, S. Ho, B. Kunz, K. Hess, G. W. Knott, V. Hatzimanikatis, F. G. van der Goot

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.

bioRxiv · Oct 1, 2018 · PreprintCell Biology