A. Lopes

Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

Productive foraging sites enhance maternal health and impact offspring fitness in a capital breeding species

This study shows that loggerhead sea turtles foraging in productive areas have better maternal health and produce fitter offspring.

Shifting KRAS hotspot mutations inhibition paradigm in colorectal cancer

This study identifies a ruthenium compound, PMC79, that selectively inhibits KRAS mutations in colorectal cancer and enhances chemotherapy efficacy.

The Ribosome Profiling landscape of yeast reveals a high diversity in pervasive translation

The paper analyzes Ribosome Profiling data in yeast to show noncoding regions exhibit diverse translation signals, including non-canonical ones, and that translation of noncoding ORFs is determined by start codon and codon distribution.

Drinkable, liquid in situ-forming and tough hydrogels for gastrointestinal therapeutics

This paper develops LIFT hydrogels that form in the stomach to deliver drugs with controlled release, improving bioavailability and reducing toxicity.

A machine learning liver-on-a-chip system for safer drug formulation

This paper develops a liver-on-a-chip system combined with machine learning to model drug metabolism and identify excipients that reduce hepatotoxicity in vivo.

Intergenic ORFs as elementary structural modules of de novo gene birth and protein evolution

This study explores how noncoding sequences in yeast can generate structural protein diversity and contribute to de novo gene birth.

Computationally guided high-throughput design of self-assembling drug nanoparticles

This paper develops a high-throughput screening platform with machine learning to design self-assembling drug nanoparticles, identifying 101 novel formulations from 2.1 million combinations.

Encapsulated mononuclear stem cells: paracrine action for the treatment of acute myocardial infarction

This study evaluates the paracrine effects of encapsulated bone-marrow mononuclear cells in a rat model of acute myocardial infarction and finds no significant therapeutic benefit.