K. Ishida

Convergent Acquisition of Glucomannan β-galactosyltransferases in Asterids and Rosids

This study identifies a convergent evolution of MBGT genes in asterids and rosids, showing different evolutionary pathways for similar biochemical functions.

An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut

This paper develops an ingestible, battery-free robotic interface for chronic gut electrostimulation, showing it can modulate ghrelin levels and has potential for treating gastrointestinal conditions.

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

A Vibrating Ingestible BioElectronic Stimulator Modulates Gastric Stretch Receptors for Illusory Satiety

The paper develops an ingestible device that activates gastric stretch receptors to reduce food intake and weight gain in swine.

Differing structures of galactoglucomannan in eudicots and non-eudicot angiosperms

This paper investigates the structural differences of galactoglucomannan in eudicots and non-eudicot angiosperms, finding that {beta}-GGM is likely eudicot-specific.

Drinkable, liquid in situ-forming and tough hydrogels for gastrointestinal therapeutics

This paper develops LIFT hydrogels that form in the stomach to deliver drugs with controlled release, improving bioavailability and reducing toxicity.

Deep learning for histopathological subtyping and grading of lung adenocarcinoma

This study develops CNNs to subtype and grade lung adenocarcinoma, achieving high accuracy and outperforming most pathologists in grading prediction.

A machine learning liver-on-a-chip system for safer drug formulation

This paper develops a liver-on-a-chip system combined with machine learning to model drug metabolism and identify excipients that reduce hepatotoxicity in vivo.

Absorbable Conductive Electrotherapeutic Scaffolds (ACES) for Enhanced Peripheral Nerve Regeneration and Stimulation

This paper introduces ACES, absorbable conductive scaffolds that enhance peripheral nerve regeneration and stimulation in animal models.

Eudicot primary cell wall glucomannan is related in synthesis, structure and function to xyloglucan

The paper shows that β-galactoglucomannan (β-GGM) in eudicot primary cell walls is structurally and functionally similar to xyloglucan (XyG).

A Novel Propidium Monoazide-Based PCR Assay Can Measure Viable Uropathogenic E. coli in Vitro and in Vivo

This paper develops a PMA-based PCR assay to detect viable uropathogenic E. coli in urine, showing it can identify live bacteria even after antibiotic treatment.

Computationally guided high-throughput design of self-assembling drug nanoparticles

This paper develops a high-throughput screening platform with machine learning to design self-assembling drug nanoparticles, identifying 101 novel formulations from 2.1 million combinations.

Interleukin-4 signaling plays a major role in urogenital schistosomiasis-associated bladder pathogenesis

This study shows IL-4 signaling is critical for bladder pathology in urogenital schistosomiasis, with IL-4 promoting urothelial proliferation and cell cycle changes.

IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways

This study identifies IPSE's mechanism in reducing ifosfamide-induced cystitis by downregulating pro-inflammatory pathways and oxidative stress responses in mouse bladders.

Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse

This study shows coffee polyphenols prevent cognitive dysfunction and reduce amyloid β plaques in APP/PS2 mice by degrading amyloid β fibrils.

Phylogenomics places orphan protistan lineages in a novel eukaryotic super-group

The paper uses phylogenomic analysis to place orphan protist lineages into a novel eukaryotic super-group, CRuMs, and clarifies their relationship to Amorphea.