V. Hatzimanikatis

Host metabolic pathways essential for malaria and related hemoparasites in the infection of nucleated cells

The paper identifies host metabolic pathways essential for malaria and related hemoparasites by combining a metabolic model and CRISPR screen.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

ATLASx: a computational map for the exploration of biochemical space

The paper maps metabolic dark matter by predicting 5 million reactions and integrating 2 million compounds into a global biochemical network called ATLASx.

Database for drug metabolism and comparisons, NICEdrug.ch, aids discovery and design

NICEdrug.ch is a database of 250,000 bio-active molecules that identifies reactive similarities to aid drug discovery, repurposing, and toxicity evaluation.

Particle-based simulation reveals macromolecular crowding effects on the Michaelis-Menten mechanism

The paper develops a particle-based simulation framework to quantify how macromolecular crowding affects the Michaelis-Menten kinetics of enzymatic reactions in Escherichia coli.

Identification and dynamics of the DHHC16-DHHC6 palmitoylation cascade

The paper identifies DHHC16 as an upstream palmitoyltransferase regulating DHHC6, revealing a palmitoylation cascade and showing dynamic interconversion of DHHC6 species.