Cancer BiologybioRxiv
Cyclin E1 protein is stabilized in BRCA1 mutated breast cancers leading to synergy between CDK2 and PARP inhibitors
D. Aziz, N. Portman, K. Fernandez…·C. E. Caldon
The paper identifies cyclin E1 stabilization in BRCA1-mutated breast cancers and shows synergy between CDK2 and PARP inhibitors in treating these cancers.
DOI 10.1038/s41523-021-00312-x