ImmunologybioRxiv
Anti-CD137 monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression
T. Masu, M. Atsukawa, K. Nakatsuka…·K. Iwakiri
This study shows that combining anti-CD137 mAb with trastuzumab enhances NK cell-mediated ADCC against HER2-low pancreatic cancer cells, particularly in individuals with FcγRIIIA-VV/VF genotype.
DOI 10.1371/journal.pone.0200664