Author

K. J. Blumer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

G. R. Bowman· 2 shared S. Singh· 2 shared A. J. Dixon· 1 shared C. M. Makepeace· 1 shared C. M. Yuede· 1 shared J. A. Cooper· 1 shared J. Choi· 1 shared K. D. Piggott· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

G. R. Bowman

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Author profile →

3 papers

Recent·Most cited

G protein activation occurs via a largely universal mechanism

N. Vithani, T. D. Todd, S. Singh, K. J. Blumer, G. R. Bowman

The paper uses simulations to study G protein activation mechanisms, finding conserved allosteric pathways and validating their dominance through experimental mutation analysis.

bioRxiv · Oct 24, 2023Biophysics

Targeting primary and metastatic uveal melanoma with a G protein inhibitor

M. D. Onken, C. M. Makepeace, K. M. Kaltenbronn, J. Choi, L. Hernandez-Aya, K. N. Weilbaecher, K. D. Piggott, P. K. Rao, C. M. Yuede, A. J. Dixon, P. Osei-Owusu, J. A. Cooper, K. J. Blumer

This study evaluates the therapeutic potential of FR, a Gq/11 inhibitor, in uveal melanoma by testing its effects on tumor growth, apoptosis, and metastasis in cell lines and xenograft models.

bioRxiv · Jan 16, 2021 · PreprintCancer Biology

Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

X. Sun, S. Singh, K. J. Blumer, G. R. Bowman

The paper simulates G protein activation to identify a new intermediate that drives GDP unbinding, revealing tilting of a helix as the rate-limiting step.

bioRxiv · Apr 23, 2018Biophysics