J. Choi

A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism

This study shows that a ketogenic diet enhances the effectiveness of glutamine metabolism inhibitors in pancreatic cancer by increasing tumor reliance on glutamine for energy.

The N-degron pathway governs autophagy to promote thermotolerance in Arabidopsis

The paper shows that ATG8a turnover via the Arg/N-degron pathway regulates autophagy and thermotolerance in Arabidopsis during heat stress.

Context-dependent roles for autophagy in myeloid cells in tumor progression

This study shows that autophagy in myeloid cells can either promote or suppress tumor growth depending on the tumor context, highlighting the need for targeted autophagy inhibitors in cancer therapy.

Portal bile acids and microbiota along the murine intestinal tract exhibit sex differences in physiology

The paper examines sex differences in gut microbiota and bile acid composition in mice, finding distinct microbial diversity and portal bile acid profiles between males and females.

Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the trans-Golgi network during virus entry

This study identifies Rab6a as essential for HPV trafficking from the TGN to the nucleus by facilitating its association with dynein and BICD2.

A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration.

This study shows that Centella asiatica extract improves age-related cognitive decline and anxiety in mice, but effects vary by sex, dose, and administration method.

Evaluating HIV Infectivity and Virion Maturation Across Varied Producer Cells with a Novel FRET-Based Detection and Quantification Assay

This study compares HIV-1 virion maturation and infectivity between Jurkat and HEK293T cells using a FRET-based assay, finding lower maturation and infectivity in Jurkat-derived virions.

Spatial dissection of cellular heterogeneity and functional crosstalk in the tumor microenvironments of gastric cancers

This study uses spatial transcriptomics to analyze gastric cancer tumor microenvironments, identifying subtypes and functional interactions between cell types that correlate with clinical outcomes.

DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time

LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

This study identifies LRRC23 as a critical component of the RS3 head in mammalian sperm, showing that its truncation leads to defective flagellar motility and male infertility.

Early life regulatory T cells modulate PPAR-gamma dependent skin pigmentation

The paper shows that early life regulatory T cells (ETregs) regulate PPAR-gamma signaling in hair follicles, which is essential for melanocyte stem cell-mediated skin pigmentation.

The origin of intestinal cancer in the context of inflammation

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.

Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation

The paper uses single-cell RNA sequencing to analyze lung-infiltrating Tregs in eosinophilic and neutrophilic allergic airway inflammation models, revealing significant heterogeneity and tissue-residency differences.

Stereotypic persistent B cell receptor clonotypes in Alzheimer's Disease

The paper identifies stereotypic BCR clonotypes in Alzheimer's Disease patients that persist over time and are not found in healthy controls, suggesting potential diagnostic signatures.

Highly effective gene inactivation in tetraploid Xenopus laevis with low-temperature-active engineered Cas12a

This study evaluates engineered Cas12a variants for gene inactivation in Xenopus laevis, finding that Cas12a-Ultra achieves high efficiency at low temperatures.

Noncanonical Rab9a action supports endosomal exit of human papillomavirus during virus entry

This study shows Rab9a inhibits HPV entry by regulating retromer interaction and endosome-to-Golgi transport, revealing a trafficking mechanism distinct from cellular proteins.

Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents

This paper introduces a flexible carbon fiber electrode-thread array for recording dopamine activity in multiple deep brain targets in rodents and demonstrates its spatial resolution and integration with histological analysis.

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

Sequence independent activity of a predicted long disordered segment of the human papillomavirus L2 capsid protein during virus entry

The paper shows that the length, not the sequence, of a disordered segment in HPV16 L2 protein determines its activity during virus entry.

An ancestral vaccine induces anti-Omicron antibodies by hypermutation

This study shows that repeated mRNA vaccination leads to BCR hypermutation, enabling antibodies to neutralize Omicron variants.

Lymphocyte activation gene 3 (Lag3) supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis

This study shows Lag3 supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis, which is critical for suppressing autoimmune inflammation.

IL-4 downregulates BCL6 to promote memory B cell selection in germinal centers

This study shows IL-4 downregulates BCL6 in GC B cells to promote memory B cell selection and regulate affinity maturation.

Sniper2L, a high-fidelity Cas9 variant with high activity

This paper develops Sniper2L, a high-fidelity Cas9 variant with improved specificity and retained high on-target activity, and introduces a deep-learning model to predict its activity.

Innate-adaptive IFN cross-talk reprograms myeloid and T cells for antitumor immunity with a second-generation recombinant MVA

This paper describes a second-generation recombinant MVA vaccine that enhances antitumor immunity by reprogramming myeloid and T cells through innate-adaptive IFN cross-talk.

Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin-beta receptor signaling

The paper shows that leukemic cells activate LTβR signaling in mesenchymal stem cells, suppressing IL7 production and lymphopoiesis while promoting leukemia growth.

Topical GZ21T inhibits the growth of actinic keratoses in a UVB induced model of skin carcinogenesis

This study evaluates a topical formulation of GZ17-6.02 (GZ21T) in a murine model of actinic keratoses, showing reduced lesion count and surface area, and prevention of progression to squamous cell carcinoma.