Cancer BiologybioRxiv
Anti-tumor efficacy of an MMAE conjugated antibody targeting cell surface TACE/ADAM17-cleaved Amphiregulin in breast cancer
K. A. Lofgren, S. Sreekumar, E. C. Jenkins…·P. A. Kenny
This study develops an antibody drug conjugate targeting a cleaved Amphiregulin epitope, showing efficacy in breast cancer models and potential as a companion diagnostic.
DOI 10.1093/abt/tbab026