K. L. Weeks

Mechanical loading reveals an intrinsic cardiomyocyte stiffness contribution to diastolic dysfunction in murine cardiometabolic disease

This study shows that cardiomyocyte stiffness contributes to diastolic dysfunction in cardiometabolic disease, identified through in vitro mechanical testing of isolated cardiomyocytes from mice with diet-induced disease.

Regulation of mitochondrial calcium uniporter expression and calcium signalling by lncRNA Tug1 in cardiomyocytes.

This study shows that lncRNA Tug1 regulates MCU expression and Ca2+ signaling in cardiomyocytes through CaMKII, affecting cardiac function.

Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology

This study uses 2D speckle tracking echocardiography to assess diastolic dysfunction in T2D mice, finding impaired strain rates and regional susceptibility in the anterior left ventricular wall.