Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19
C. Baker, D. Duso, N. Kothapalli, T. Hart, S. Casey, L. Kummer, T. Cookenham, J. Hvizdos, K. Lanzer, P. Vats, P. Shanbhag, I. Bell, M. Tighe, K. Travis, F. Szaba, , N. Rosenthal
The paper characterizes the CAST/EiJ mouse strain as a model for severe COVID-19 by showing it develops high viral burdens, severe lung pathology, and cytokine dysregulation leading to mortality.
bioRxiv · Apr 26, 2024Immunology