Author

K. LeGault

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Angermeyer· 2 shared K. Seed· 2 shared M. Alam· 2 shared A. Arellano· 1 shared A. C. McKitterick· 1 shared A. Coe· 1 shared A. McKitterick· 1 shared A. N. Rasmussen· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

A. Angermeyer

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4 papers

Recent·Most cited

A phage parasite deploys a nicking nuclease effector to inhibit replication of its viral host

K. LeGault, Z. Barth, P. DePaola, K. Seed

This study identifies a phage-encoded nuclease, NixI, that inhibits replication of its viral host ICP1 by nicking its genome, preventing efficient packaging.

bioRxiv · Jul 12, 2021Microbiology

Temporal Shifts in Antibiotic Resistance Elements Govern Virus-Pathogen Conflicts

K. LeGault, S. G. Hays, A. Angermeyer, A. C. McKitterick, F.-t. Johura, M. Sultana, M. Alam, K. D. Seed

The paper shows that fluctuations in SXT ICEs govern Vibrio cholerae susceptibility to phages in clinical samples, with phage counter-adaptation and SXT ICE dissemination observed.

bioRxiv · Dec 16, 2020Microbiology

Coping with darkness: The adaptive response of marine picocyanobacteria to repeated light energy deprivation

A. Coe, S. Biller, E. Thomas, K. Boulias, C. Bliem, A. Arellano, K. Dooley, A. N. Rasmussen, K. LeGault, T. J. O'Keefe, E. L. Greer, S. W. Chisholm

This study shows Prochlorococcus and Synechococcus can adapt to repeated light deprivation, with an epigenetic mechanism involved, though no DNA methylation was detected in the tested strain.

bioRxiv · Oct 15, 2020Microbiology

Competition between mobile genetic elements drives optimization of a phage-encoded CRISPR-Cas system: Insights from a natural arms-race

A. McKitterick, K. LeGault, A. Angermeyer, M. Alam, K. Seed

The paper studies CRISPR-Cas spacer acquisition and interference in a phage-against-mobile-genetic-element arms race, finding that chromosomal spacers can block PLE mobilization.

bioRxiv · Aug 1, 2018Microbiology