E. Thomas

Emergence of metabolic coupling to the heterotroph Alteromonas promotes dark survival in Prochlorococcus

The paper shows that Prochlorococcus develops a dark-tolerant phenotype when co-cultured with Alteromonas, involving metabolic coupling and shifts in gene expression.

The proteome of agroinfiltrated Nicotiana benthamiana is shaped by extensive protein processing

The paper identifies extensive proteolytic processing of plant proteins in agroinfiltrated N. benthamiana using peptographs and mass spectrometry, revealing widespread proteoform modifications.

Molecular control of the lymphocyte death timer

The paper identifies a protein-threshold mechanism that predicts lymphocyte death timing and shows how it integrates signals and is heritable across generations.

Colorectal cancer detection and treatment with engineered probiotics

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

Potential selection and maintenance of manure-originated multi-drug resistant plasmids at sub-clinical antibiotic concentrations

This study determines the minimum selection concentrations of antibiotics for manure-originated multi-drug resistant plasmids in E. coli, showing they can be maintained in environmentally relevant concentrations.

3D-bioprinted, phototunable hydrogel models for studying adventitial fibroblast activation in pulmonary arterial hypertension

This paper develops a 3D-bioprinted hydrogel model to study fibroblast activation in pulmonary arterial hypertension, showing increased fibrotic and proliferative markers in stiffer matrices.

Chitin utilization by marine picocyanobacteria and the evolution of a planktonic lifestyle

This study shows marine picocyanobacteria utilize chitin, linking their planktonic lifestyle evolution to chitin degradation and ecological expansion.

Metabolic strategies shared by basement residents of the Lost City hydrothermal field

This study identifies key microbial species and metabolic strategies in hydrothermal fluids from the Lost City field, revealing adaptations to geochemically driven energy sources.

TAL effectors with avirulence activity in African strains of Xanthomonas oryzae pv. oryzae

The paper identifies and characterizes two TALEs, TalD and TalI, from an African Xanthomonas oryzae pv. oryzae strain that act as avirulence factors in rice.

Novel integrative elements and genomic plasticity in ocean ecosystems

The paper identifies tycheposons, mobile genetic elements in Prochlorococcus, that drive genomic plasticity through gene exchange and contribute to microbial adaptation in ocean ecosystems.

Coping with darkness: The adaptive response of marine picocyanobacteria to repeated light energy deprivation

This study shows Prochlorococcus and Synechococcus can adapt to repeated light deprivation, with an epigenetic mechanism involved, though no DNA methylation was detected in the tested strain.

Microbial Diversity of Co-occurring Heterotrophs in Cultures of Marine Picocyanobacteria

The paper examines microbial diversity in cultures of marine picocyanobacteria, finding that heterotroph community composition varies with host ecotype and isolation conditions, while some bacteria are consistently abundant.

Association of lanthipeptide genes with TnpAREP transposases in marine picocyanobacteria

The paper investigates the association between lanthipeptide genes and TnpAREP transposases in marine picocyanobacteria, suggesting a potential diversifying recombination mechanism for prochlorosin expansion.

Variation in the plasma membrane monoamine transporter (PMAT, encoded in SLC29A4) and organic cation transporter 1 (OCT1, encoded in SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study

This study investigates the association between genetic variants in PMAT and OCT1 transporters and metformin gastrointestinal intolerance in type 2 diabetes patients.

A novel real-time PCR assay panel for detection of common respiratory pathogens in a convenient, strip-tube array format

The paper develops and validates a real-time PCR assay (Respanel) for detecting respiratory pathogens, showing higher sensitivity than Resplex and comparable performance to FTDRP21.