Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia
X. Zhao, K. Lorent, D. Escobar-Zarate, R. Rajagopalan, K. Loomes, K. Gillespie, C. Mesaros, M. Estrada, I. Blair, J. Winkler, N. Spinner, M. Devoto, M. Pack
This study identifies redox and protein homeostasis as key factors in toxin-induced biliary atresia, showing that genetic modulation of these pathways affects cholangiocyte injury and suggesting potential therapeutic strategies.
bioRxiv · Apr 30, 2020Pathology