C. Mesaros

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells

This study shows that metabolic activity in cancer cells affects circadian rhythms, with hypermetabolic states linked to weaker circadian oscillations in both mouse and human tumor cells.

Acyl-CoA thioesterase-2 facilitates beta-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner

This study shows ACOT2 regulates acyl-CoA levels in glycolytic muscle, promoting β-oxidation when lipid supply is low but causing lipid accumulation and poor glucose homeostasis when lipid supply is high.

Biliatresone treatment of pregnant mice causes changes in bile metabolism and liver inflammation in their offspring

This study shows that prenatal exposure to low-dose biliatresone in mice leads to altered bile metabolism and liver inflammation in offspring without histological damage.

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

This study shows that glutamine deprivation in pancreatic ductal adenocarcinoma cells increases free GlcNAc and activates NAGK-dependent hexosamine salvage to support tumor growth.

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia

This study identifies redox and protein homeostasis as key factors in toxin-induced biliary atresia, showing that genetic modulation of these pathways affects cholangiocyte injury and suggesting potential therapeutic strategies.

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry

This paper develops a method to simultaneously quantify and trace dNTP metabolites using isotope dilution and high-resolution mass spectrometry, showing improved accuracy and metabolic pathway insights.

Artefactual formation of pyruvate from in-source conversion of lactate

The paper identifies an artefactual pyruvate formation from lactate during LC-MS analysis, highlighting the need for improved resolution or quantification in metabolomics studies.