Cell BiologybioRxivPreprint
SARS-CoV-2 Envelope-mediated Golgi pH dysregulation interferes with ERAAP retention in cells
V. Vargas-Zapata, K. M. Geiger, D. Tran…·L. Coscoy
This study identifies SARS-CoV-2 Envelope protein-induced Golgi pH neutralization as a mechanism causing ERAAP loss and extracellular release, highlighting ERAAP as a sensor of secretory pathway disturbances during infection.
DOI 10.1101/2022.11.29.518257