K. Moissoglu

A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions

The paper identifies CNBP as a factor required for mRNA localization to cell protrusions by forming a motor-adaptor complex with KIF1C.

mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations

The paper shows that mRNA location and translation rate influence protein targeting to multiple destinations by modulating interactions with scaffold proteins and importins.

The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions

The paper identifies KIF1C as a motor transporting APC-dependent mRNAs to cell protrusions, showing its dual role in RNA transport and clustering.

Local RNA translation controls cell migration and Rab GTPase function

The paper shows that local RNA translation of RAB13 at cellular protrusions is required for full activation of the GTPase and efficient cell migration, mediated by its association with RABIF.

Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

This study shows protrusion-localized RNAs are translated in both extending and retracting protrusions, but become silenced and cluster in retracting protrusions.