F. Mueller

Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells

This study identifies the epigenetic signature and key transcription factors regulating human antigen-specific Tr1 cells, revealing their unique biology and potential for therapeutic applications.

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

The paper identifies TBKBP1 as a key gene whose demethylation enhances cytotoxic activity in CMV-specific CD8+ T cells, suggesting it as a therapeutic target.

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPAR alpha and PCK1 action in hepatocytes

This study shows intermittent fasting prevents NASH and HCC by PPAR alpha and PCK1 working together in liver cells.

A phase-separated biomolecular condensate nucleates polymerization of the tubulin homolog FtsZ to spatiotemporally regulate bacterial cell division

The paper shows PomY forms liquid-like condensates that nucleate FtsZ polymerization, guiding bacterial cell division site positioning through surface-assisted condensation.

Mer3 helicase protects early crossover intermediates from STR complex disassembly during meiosis

This study identifies a new Mer3 complex with Top3 and Rmi1 and shows Mer3 inhibits the STR complex's anti-recombination activity, promoting crossover formation during meiosis.

ReSurveyGermany: Vegetation-plot time-series over the past hundred years in Germany

The paper compiles and harmonizes vegetation-plot resurvey data from Germany over almost 100 years, enabling analysis of biodiversity change and species distribution shifts.

Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin

The paper shows Spindly adopts a closed conformation that blocks Dynein-Dynactin binding, and mutations induce an open state that enables interaction, with kinetochores promoting Spindly activation.

Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

The paper develops and compares protocols to produce and use highly active CDK1:Cyclin-B and CDK1:Cyclin-B:CKS1 complexes for mitotic protein machinery studies.

RNA labelling in live plants reveals single cell transcriptional dynamics: application to phosphate signaling

The paper uses RNA imaging in live Arabidopsis plants to study single-cell transcriptional dynamics, finding rapid transcriptional repression in response to phosphate and high intrinsic noise.

Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH

This paper introduces CoronaFISH, a method to visualize SARS-CoV-2 RNA in cells and tissues, demonstrating its sensitivity and applicability in various biological contexts.

Hydroxyapatite pellets as versatile model surfaces for systematic studies on enamel

This study evaluates hydroxyapatite pellets as a model surface for studying bacterial adhesion, finding similar adhesion properties to enamel under various conditions.

The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions

The paper identifies KIF1C as a motor transporting APC-dependent mRNAs to cell protrusions, showing its dual role in RNA transport and clustering.

Chromoplast differentiation in bell pepper (Capsicum annuum) fruits

This study identifies proteomic changes during chromoplast differentiation in bell pepper fruits, highlighting key metabolic and structural adaptations.

A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51/MCART1 in mitochondrial NAD uptake

The paper systematically maps genetic interactions among human solute carriers, identifying SLC25A51/MCART1 as a mitochondrial NAD(H) transporter.

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

This study identifies Mer2 as a keystone in meiotic DSB formation by linking it to chromatin and DSB factors through biochemical interactions.

Remodeling of the core leads HIV-1 pre-integration complex in the nucleus of human lymphocytes.

This study reveals how HIV-1 CA proteins remodel into a 'pearl necklace' structure around viral DNA to facilitate nuclear entry in human lymphocytes.

Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages

This study shows HIV-1 RNA clusters in macrophage nuclei, where reverse transcription and DNA formation occur, challenging the view that these processes are spatially and temporally separated.

Clathrin’s adaptor interaction sites are repurposed to stabilize microtubules during mitosis

This paper identifies a novel role of clathrin in stabilizing microtubules during mitosis by repurposing its adaptor interaction sites to recruit GTSE1, which inhibits MCAK and supports chromosome congression.