M. Peter

Mild hyperthermia-induced thermogenesis in the endoplasmic reticulum defines stress response mechanisms

The paper shows mild hyperthermia induces ER thermogenesis and UPR activation in cells, leading to different stress responses in MEF and U2OS cells.

Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy

This study identifies Stm1's role in promoting ribosome biogenesis by regulating Ifh1 activity, revealing a link between ribosome biogenesis and dormancy.

Structural features of heteromeric channels composed of CALHM2 and CALHM4 paralogs

This study investigates whether CALHM2 and CALHM4 form heteromers and characterizes their structural properties.

The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration

This study identifies GID4 as a substrate receptor of the hGID E3 ligase complex that targets ARHGAP11A for degradation, thereby regulating cell migration.

Oxidation-sensitive cysteines drive IL-38 amyloid formation

This study identifies oxidation-sensitive cysteines in IL-38 that drive amyloid formation under oxidative stress, suggesting a new biological role for IL-38 in epithelial barriers.

The CRL4B E3 ligase regulates mitosis by recruiting phospho-specific DCAFs

This study identifies LIS1 and WDR1 as CUL4B-specific DCAFs that bind via phosphorylation, essential for mitosis and brain development, but not the CUL4B-P50L mutant.

A conserved mechanism regulates reversible amyloids via pH-sensing regions

This study identifies a conserved mechanism by which pH-sensing regions regulate reversible amyloid formation in pyruvate kinase across yeast and human cells.

Interorganelle lipid flux revealed by enzymatic mass tagging in vivo

This study introduces METALIC, a method to track interorganelle lipid flux in vivo, and shows ERMES and Vps13-Mcp1 complexes mediate ER-mitochondria lipid exchange.

Rewiring phospholipid biosynthesis reveals robustness in membrane homeostasis and uncovers lipid regulatory players.

The paper rewires phospholipid synthesis in yeast to study membrane homeostasis and identifies Csf1 as a lipid transport regulator.

The human GID complex engages two independent modules for substrate recruitment

This study identifies two distinct modules in the human GID complex for substrate recruitment, revealing different roles for WDR26 and GID4 in ubiquitination and substrate recognition.

The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions

The paper identifies KIF1C as a motor transporting APC-dependent mRNAs to cell protrusions, showing its dual role in RNA transport and clustering.

A conserved choreography of mRNAs at centrosomes reveals a localization mechanism involving active polysome transport

The paper identifies conserved centrosomal mRNAs that localize via active polysome transport mediated by nascent proteins, using human and Drosophila models.

Coincidence detection of mitogenic signals via cytosolic pH regulates Cyclin D1 expression

The paper shows that elevated cytosolic pH regulates Cyclin D1 expression through E2F-dependent transcription and CREB1-p300/CBP interaction, linking pH changes to cell proliferation and cancer progression.

A localization screen reveals translation factories and widespread co-translational RNA targeting

The paper identifies translation factories and co-translational RNA targeting through a dual protein/mRNA localization screen in human cells.

Visual Biochemistry: modular microfluidics enables kinetic insight from time-resolved cryo-EM

This paper introduces a time-resolved cryo-EM method using modular microfluidics to visualize biochemical reactions at near-atomic resolution and millisecond timescales, demonstrating its application to RecA filament formation.

Microhabitat and ectomycorrhizal effects on the establishment, growth and survival of Quercus ilex L. seedlings under drought

This study examines how microhabitat conditions and ectomycorrhizal (ECM) associations affect Quercus ilex seedling survival and growth under drought conditions.

Delineating the rules for structural adaptation of membrane-associated proteins to evolutionary changes in membrane lipidome

The paper investigates how changes in membrane lipid composition drive structural adaptations in membrane-associated proteins across two fission yeast species.

CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

This study identifies CSNAP as a key subunit of the CSN complex that modulates CRL activity through steric inhibition, affecting cell viability and DNA damage response.

Identification of DISE-inducing shRNAs by monitoring cellular responses

The paper identifies DISE-inducing shRNAs by testing their effects on cancer cells and shows DISE is a specific cellular response, not random off-target effects.

Induction of DISE in ovarian cancer cells in vivo

This study shows that DISE can be induced in ovarian cancer cells in vivo using siRNA-TLPs, leading to tumor growth reduction.

Filopodyan: An Open-Source Pipeline For The Analysis Of Filopodia

Filopodyan quantifies fluorescence and dynamics of filopodia in multiple cell types, revealing molecular heterogeneity in ENA/VASP recruitment during filopodia formation.