Cell BiologybioRxiv
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains
O. Huynh, K. Ruis, K. Montales, W. M. Michael
This study identifies two distinct interaction sites between NBS1 and TOPBP1, showing direct binding through their BRCT domains without requiring intact domains or post-translational modifications.
DOI 10.1016/j.dnarep.2023.103461