Cancer BiologybioRxiv
Identifying targetable metabolic dependencies across colorectal cancer progression
D. N. Legge, E. Stanko, A. K. Holt…·E. E. Vincent
This study identifies asparagine synthesis as a metabolic vulnerability in late-stage colorectal cancer cells, showing that blocking asparagine synthetase inhibits their proliferation.
DOI 10.1016/j.molmet.2024.102037