BiophysicsbioRxiv
Rapid Assessment of T-Cell Receptor Specificity of the Immune Repertoire
X. Lin, J. T. George, N. P. Schafer…·H. Levine
This paper introduces RACER, a pairwise energy model that assesses TCR-peptide affinity using supervised machine learning, demonstrating its utility in simulating thymic selection and estimating recognition rates for tumor antigens.