Author

K. Pethe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

A. Aubry· 1 shared A. Chauffour· 1 shared A. Firras· 1 shared G. Pluschke· 1 shared H. JIA· 1 shared H. Q. V. KOH· 1 shared I. H. Gao· 1 shared J. Lescar· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperMicrobiology

A. Aubry

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4 papers

Recent·Most cited

An essential protease, FtsH, influences daptomycin resistance acquisition in Enterococcus faecalis

Z. J. Nair, I. H. Gao, A. Firras, K. K. L. Chong, P. Y. Choo, K. Pethe, K. A. Kline

This study identifies FtsH as a key factor influencing the speed of daptomycin resistance acquisition in Enterococcus faecalis through its role in regulating HrcA and metabolic processes.

bioRxiv · Jul 31, 2023 · PreprintMicrobiology

Toward a single dose cure for Buruli ulcer

S. Thomas, N. P. Kalia, M.-T. Ruf, G. Pluschke, K. Pethe

A single dose of TELACEBEC (Q203) eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer without relapse.

Antimicrobial Agents and Chemotherapy · Aug 20, 2020Peer-reviewedMicrobiology

HflX controls hypoxia-induced non-replicating persistence in slow growing mycobacteria

J. Y. G. NGAN, S. PASUNOOTI, W. TSE, W. MENG, S. F. C. NGAN, S. W. NG, M. T. JAAFAR, H. JIA, S. L. S. CHO, J. LIM, H. Q. V. KOH, N. ABDULGHANI, K. PETHE, K. S. Sze, J. Lescar, S. Alonso

This study shows HflX in slow-growing mycobacteria enables hypoxia-induced non-replicating persistence, contributing to drug tolerance and dormancy.

bioRxiv · Mar 13, 2020 · PreprintMicrobiology

Q203 containing fully intermittent oral regimens exhibited high sterilizing activity against Mycobacterium ulcerans in mice

A. Chauffour, J. Robert, N. Veziris, A. Aubry, K. Pethe, V. Jarlier

The paper evaluates the bactericidal and sterilizing activity of Q203 in intermittent oral regimens against Mycobacterium ulcerans in mice, finding high sterilizing activity with combined regimens.

bioRxiv · Oct 21, 2019Microbiology