W. Meng

CAMSAP3 Forms Dimers via its lapha-helix Domain that Directly Stabilize Non-centrosomal Microtubule Minus Ends

This study identifies how CAMSAP3 dimerizes via its C-terminal alpha-helix to stabilize non-centrosomal microtubule minus ends through enhanced CKK domain binding.

MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migration

This study identifies MARK2 as a regulator of Golgi reorientation during cell migration by phosphorylating CAMSAP2 at serine 835, affecting its interaction with USO1.

YAP promotes chromosomal instability by transcriptionally activating AJUBA through its super enhancer in breast cancer

This study identifies YAP's role in promoting chromosomal instability in breast cancer by activating AJUBA through its super enhancer, leading to AURKA activation and aberrant mitosis.

Exploring information exchange between Thesium chinense and its host Prunella vulgaris through joint transcriptomic and metabolomic analysis

This study identifies 5 transferred metabolites and 668 mobile genes between Thesium chinense and its host Prunella vulgaris, revealing information exchange critical for haustoria formation and parasitism.

METTL16 Controls Kaposi's Sarcoma-Associated Herpesvirus Replication by Regulating S-Adenosylmethionine Cycle

This study shows METTL16 suppresses KSHV lytic replication by regulating the SAM cycle and redox homeostasis.

In vivo Ontogeny of human forebrain neural progenitor cell grafts in adult rats: an immunohistological study

This study tracks human neural progenitor cell grafts in adult rats up to 9 months, revealing their migration and differentiation patterns, and highlights their potential for neural repair.

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

This study identifies HERC5-catalyzed ISGylation of cGAS as a mechanism that enhances antiviral innate immunity by modulating the cGAS-STING pathway.

N6-methyladenosine (m6A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infections

The paper shows that m6A and YTHDF2 regulate DUSP1 to enhance innate immune response during infections by promoting DUSP1 degradation and activating MAPKs.

Changes of urinary proteome in an ApoE-/- mouse model of atherosclerosis

This study uses urinary proteomics in ApoE-/- mice to identify early biomarkers of atherosclerosis by comparing high-fat diet-induced changes with control groups.

A dataset of 5 million city trees: species clustering and climate effects in urban forests

The paper presents a dataset of 5 million city trees and analyzes species clustering, nativity status, and climate effects in urban forests.

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

Changes in the urinary proteome in rats with regular swimming exercise

This study identifies changes in the urinary proteome of rats undergoing regular swimming exercise, showing distinct protein differences linked to glucose metabolism and immunity.

Sex-specific differences in the function and differentiation of ABCsmark TLR7-driven immunopathogenesis

The paper shows sex-specific differences in ABCs expansion, ISG signature upregulation, and differentiation in TLR7-driven immunopathogenesis, with Tlr7 duplication in males exacerbating disease severity.

Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitinspecific protease C-terminally tail-anchored in the endoplasmic reticulum

This paper identifies USP19 as a modulator of Nrf1 stability and activity by preventing its ubiquitination and degradation, showing its role in tumor growth regulation.

Increased isoDGR motifs in plasma fibronectin are associated with atherosclerosis through facilitation of vascular fibrosis

This study shows that deamidated fibronectin with isoDGR motifs promotes vascular fibrosis and atherosclerosis by enhancing integrin signaling and leukocyte recruitment.

Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

The paper identifies broad immune perturbations in severe COVID-19, including innate and adaptive immune cell changes and heterogeneity in B cell responses and antibody production.

HflX controls hypoxia-induced non-replicating persistence in slow growing mycobacteria

This study shows HflX in slow-growing mycobacteria enables hypoxia-induced non-replicating persistence, contributing to drug tolerance and dormancy.

Chronic viral infection promotes early germinal center exit of B cells and impaired antibody development.

This study shows chronic viral infection disrupts GC B cell fate decisions, leading to early exit and impaired antibody development.

Urine proteome changes in rats with approximately ten tumor cells subcutaneous inoculation.

This study shows urine proteome changes occur in rats with approximately ten tumor cells, indicating early cancer detection potential through urine analysis.

Dynamic changes in the urine proteome in two ovarian cancer rat models

This study identifies differentially expressed urine proteins in two ovarian cancer rat models, suggesting their potential for early detection and monitoring of ovarian cancer progression.

CRISPR-Cas9 screening of KSHV-transformed cells identifies XPO1 as a vulnerable target of cancer cells

This study identifies XPO1 as a vulnerable target in cancer cells using CRISPR-Cas9 screening in KSHV-transformed cells, showing its role in cell proliferation and growth transformation.

Early urinary protein changes in the tumor-forming process of the NuTu-19 lung metastasis

This study identifies early urinary protein changes that differentiate tumor-forming from non-tumor-forming rats in a lung metastasis model.

Dynamic urinary proteomic analysis in a Walker 256 intracerebral tumor model

The paper analyzes urinary proteomic changes in a rat brain tumor model to identify early biomarkers of tumor progression and differences between tumor growth locations.