J. Lim

Hierarchical structural organization in bioinspired peptide coacervate microdroplets

This paper investigates the structural organization of peptide coacervate microdroplets using spectroscopy and microscopy, revealing dynamic interactions and cargo sequestration mechanisms.

A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.

Thermostable in vitro transcription-translation for enzyme screening in microdroplets

This paper develops a thermostable in vitro transcription-translation system using Thermus thermophilus extracts for enzyme screening in microdroplets.

The role of ultradian rhythms in post-deprivationrebounds and diurnal rhythms of sleep and wakefulness in rats

This study investigates ultradian rhythms in sleep and wakefulness in rats after sleep deprivation, finding that rebounds in wakefulness and NREM sleep depend on full ultradian cycles and are mediated by changes in ultradian phase duration and arousal probability.

Macrophages control pathological interferon responses during viral respiratory infection

This study identifies macrophage-derived Oncostatin M as a critical regulator of type I interferon responses during viral respiratory infection, preventing excessive inflammation.

Clustering of HR+/HER2- breast cancer in an Asian cohort is driven by immune phenotypes

This study identifies immune phenotype-driven clustering in HR+/HER2- breast cancer from an Asian cohort, deviating from the luminal A-luminal B classification seen in European populations.

Comparing virtual staining artificial intelligence model performance on same-tissue versus serial-tissue sections based on CD3+ T-cell ground truth

This study compares a virtual staining AI model's performance on same-tissue versus serial-tissue sections using CD3+ T-cell ground truth, finding better performance with same-tissue data.

Continuous Tracking using Deep Learning-based Decoding for Non-invasive Brain-Computer Interface

This paper develops deep learning-based decoders for continuous brain-computer interface (BCI) control and shows they improve performance over time and outperform traditional methods in complex tasks.

Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

Spatial correspondence in relative space regulates serial dependence

The paper tests how serial dependence is influenced by spatial correspondence in relative versus absolute space, finding stronger effects from relative space.

Telomeric repeat evolution in the phylum Nematoda revealed by high-quality genome assemblies and subtelomere structures

The paper analyzes telomeric repeat motifs in nematodes using genome assemblies and subtelomere structures to reveal evolutionary changes in TRMs.

Effect of acute ultraviolet radiation on Galleria mellonella health and immunity

This study examines the effects of acute UV radiation on Galleria mellonella larvae, showing reduced survival, increased infection susceptibility, and immune-related changes.

The microbial composition and functional roles of different kombucha products in Singapore

This study compares the microbial composition and functional pathways of nine commercial kombucha products in Singapore using shotgun metagenomic sequencing.

Immune-modulatory effects of low dose γ-radiation on wax moth (Galleria mellonella) larvae

This study examines the immune-modulatory effects of low-dose gamma radiation on wax moth larvae, finding dose-dependent changes in immune responses and survival.

A low-power communication scheme for wireless, 1000 channel brain-machine interfaces

This paper evaluates a pulse-interval modulation (PIM) communication scheme for wireless brain-machine interfaces, finding it reduces power consumption while maintaining accurate neural signal transmission.

Stain-free nucleus identification in holographic learning flow cyto-tomography

This paper introduces a computational method to identify cell nuclei in stain-free holographic flow cytometry data using statistical inference, validated against confocal microscopy.

Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases

PASTE enables efficient, programmable gene integration without DNA breaks, applicable for research, cell engineering, and gene therapy.

Molecular Drivers of Tumor Progression in Microsatellite Stable APC Mutation-Negative Colorectal Cancers

The paper identifies two distinct subtypes of APC mutation-negative colorectal cancers characterized by mitochondrial activation or WNT pathway sensitivity.

Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule

This study identifies the structural basis of Tax-1 interaction with syntenin-1 and demonstrates small-molecule inhibition of this interaction to target HTLV-1.

FEATURE DETECTION TO SEGMENT CARDIOMYOCYTE NUCLEI FOR INVESTIGATING CARDIAC CONTRACTILITY

This paper introduces an improved feature detection framework to segment cardiomyocyte nuclei in zebrafish hearts, enabling quantitative analysis of cardiac contractility across developmental stages.

Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

The paper identifies immune signatures associated with COVID-19 severity and temporality, revealing distinct patterns and providing tools for data analysis.

Proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

This study shows that loss of Atg16l1 in macrophages enhances antimicrobial immunity against Shigella flexneri via the oxidative stress response.

Genetic and Genomic Resources to Study Natural Variation in Brassica rapa

The paper constructs an AI-RIL population and generates a de novo genome assembly for B. rapa to study natural variation and improve genetic mapping resolution.

HflX controls hypoxia-induced non-replicating persistence in slow growing mycobacteria

This study shows HflX in slow-growing mycobacteria enables hypoxia-induced non-replicating persistence, contributing to drug tolerance and dormancy.

Multiplex generation, tracking, and functional screening of substitution mutants using a CRISPR/retron system

This paper develops a CRISPR/retron system for high-throughput generation and tracking of substitution mutations in E. coli, enabling genome-scale screening of chemical responses and fitness changes.

Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids

This study shows adiponectin and related CTRP proteins bind to anionic phospholipids and sphingolipids, suggesting they function as lipid-binding opsonins or carriers.

MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure

The paper identifies MISTERMINATE as a mechanism linking mitochondrial dysfunction to proteostasis failure through translational termination impairment and C-terminal extension of mitochondrial proteins.

Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

This study investigates the use of magnetic field gradients to manipulate magnetic nanoparticles and induce cancer cell death in vitro.

Three-dimensional human axon tracts derived from cerebral organoids

This paper describes the generation of three-dimensional human axon tracts from cerebral organoids, which can be transplanted and mimic brain connectivity features.