Pharmacology & ToxicologybioRxivPreprint
Blockade of SARS-CoV-2 infection in-vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor
A. Acharya, K. Pandey, M. Thurman…·S. N. Byrareddy
The paper demonstrates that SF2523, a PI3K-α/mTOR/BRD4 inhibitor, effectively blocks SARS-CoV-2 replication in vitro with an IC50 of 1.5 μM and shows synergy with remdesivir.
DOI 10.1101/2021.03.02.433604