Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells
L. E. Lucca, P.-P. Axisa, B. Lu, B. Harnett, S. Jessel, L. Zhang, K. Raddassi, L. Zhang, K. Olino, J. Clune, M. Singer, H. Kluger, D. A. Hafler
The paper examines circulating T cells sharing TCRs with tumor-infiltrating T cells in metastatic melanoma patients, finding they exhibit effector gene signatures similar to tumor T cells.
Journal of Experimental Medicine · Mar 2, 2021Peer-reviewedImmunology